Importance of Dose Initiation and Titration
Ongoing patient assessment is key to managing outcomes.
Titration hinges on pain severity, patient response, and occurrence of adverse reactions.6
When deciding on initial dose of PRIALT, assessing your patient’s condition is key to managing the pain. Initiate dosing at no more than 2.4 mcg/day.6
The lowest initial starting dose of PRIALT that can be delivered through the Medtronic SynchroMed® II pump without dilution is 1.2 mcg/day. Example:
- Lowest flow rate = 0.048 mL/day15
- 25 mcg/mL × 0.048 mL/day = 1.2 mcg/day
When titrating up to 2.4 mcg/day, you can always opt to titrate to a lower dose and/or titrate less frequently. The maximum dose should not exceed 19.2 mcg/day.
Important Safety Information
MOST COMMON ADVERSE REACTIONS
The most frequently reported adverse reactions (≥25%) in clinical trials (n=1254 PRIALT-treated patients) were dizziness, nausea, confusional state, and nystagmus. Slower titration of PRIALT may result in fewer serious adverse reactions and discontinuations for adverse reactions.