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A Different Mechanism of Action
PRIALT is a different type of calcium channel blocker and hence, a different non-opioid analgesic.
Results in animal model studies suggest that PRIALT exerts its antinociceptive effect(s) by selectively blocking the pre-synaptic N-type calcium channels and reducing the release of excitatory neurotransmitters from the primary afferent nerve terminals. The mechanism of action has not been established in humans, however human studies have shown that PRIALT provides antinociceptive effects only when administered by the IT route.
This unique mechanism of action gives physicians a different option when treating severe chronic pain. - PRIALT does not bind to opioid receptors
- PRIALT does not potentiate opiate-induced respiratory depression
- No evidence of physiological tolerance or dependency with PRIALT seen in clinical trials
Because PRIALT is not an opiate, it cannot prevent or relieve the symptoms associated with opiate withdrawal.
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is a trademark of Elan Pharmaceuticals, Inc.