How Is Pain Felt?


  • When something triggers pain, a sensory signal is transmitted, traveling from the site of injury, along your nerves, and up through your spine until it reaches your brain3,4
  • The brain then interprets the signal as pain and sends the pain message back to the site3
  • In order to get to your brain, the pain signal must travel along nerves, passing through nerve channels3,4
  • Chemical helpers in your body cross the gaps between nerves and aid the signal as it travels to the brain along the nerve pathways3,4
  • One of the nerve pathways is called the N-type calcium channel3,5
  • When you block the N-type calcium channel, you may reduce the pain3-5

Safety Information

  • Tell your doctor about all the medicines you are taking.
  • Meningitis (inflammation of the protective membranes covering the brain and spinal cord) or other infections can happen if the infusion device becomes contaminated. Tell your doctor right away if you have fever, headache, stiff neck, changes in mental status (feeling tired, confused, disoriented), nausea, vomiting, and/or seizures as these may be symptoms of developing meningitis.
  • PRIALT may cause unconsciousness or reduced mental alertness. Avoid activities where you need to be alert, awake, and have full control of your body (activities like operating machinery or driving a car) during treatment with PRIALT.

Click here for additional Important Safety Information, and please see full Prescribing Information, including BOXED Warning, and discuss with your doctor.

References: 3. McGivern JG. Targeting N-type and T-type calcium channels for the treatment of pain. Drug Discov Today. 2006;11(5-6):245-253. 4. McGivern JG. Ziconotide: a review of its pharmacology and use in the treatment of pain. Neuropsychiatr Dis Treat. 2007;3(1):69-85. 5. McGivern JG. Voltage-gated calcium channels as targets for the treatment of chronic pain. Curr Drug Targets CNS Neurol Disord. 2004;3(6):457-478.