Actor portrayal.

INDICATION

PRIALT is a prescription medicine used to treat severe chronic pain in adults who cannot take other treatments or when other treatments do not work, stop working, or cause bothersome side effects. PRIALT can only be delivered by or under the direction of a doctor who injects the medicine into your spinal fluid through a special device (a procedure called intrathecal infusion) and should only be used in patients who are appropriate for the procedure.

Discover
long-term,*
non-opioid pain relief

*PRIALT was studied in multiple open-label, long-term safety studies for up to 12 months.

INDICATION

PRIALT is a prescription medicine used to treat severe chronic pain in adults who cannot take other treatments or when other treatments do not work, stop working, or cause bothersome side effects. PRIALT can only be delivered by or under the direction of a doctor who injects the medicine into your spinal fluid through a special device (a procedure called intrathecal infusion) and should only be used in patients who are appropriate for the procedure.

How your medication is delivered matters

Pain signals travel from the site of injury through nerve channels in the spine to reach the brain. With intrathecal therapy (IT), a pump is placed in the body with a catheter that delivers medication directly into the spinal fluid. The line can be placed close to where your specific injury or problem is located. IT therapy may help reduce the amount of oral medication you use to block pain because the medication enters the body right where pain signals travel.


avatar nerves graphic

You may be experiencing more than one type of pain

Your severe chronic pain condition may be a result of more than one cause – damage to body tissues (nociceptive), damage to the nervous system (neuropathic), or a mix of the two. These causes of pain can be described as pain types.

 Diagram of human body with spine and brain highlighted. Pain is reduced; not all patients will have the same level of pain relief from PRIALT (pointing to brain). Pain signal interrupted (pointing to spine). Nerve channels; eg, N-type calcium channel –(pointing to lower back/spine). PRIALT enters spinal fluid channel (pointing to lower back/spine). Site of injury/pain (pointing to lower back/spine). Magnified section showing intrathecal pump

Pain that is partly neuropathic can show up in many different conditions:

  • Diabetic neuropathy
  • HIV-related neuropathy
  • Complex regional pain syndrome
  • Multiple sclerosis
  • Lumbar radiculopathy
  • Failed back surgery syndrome
  • Cancer-related pain
  • Spinal cord injury
  • Phantom limb
  • Tumor compression
This list does not cover all of the pain conditions that have neuropathic pain.

Neuropathic pain may not respond well to medications

PRIALT, like opioids, has been studied in many types of severe chronic pain, but may not be appropriate for all patients.

Is PRIALT right for you?

Ask your doctor about PRIALT

Starting on PRIALT?

What you need to know about starting therapy

Questions about treatment?

Contact a nurse who specializes in non-opioid intrathecal treatment for severe chronic pain

Important Safety Information and Indication

PRIALT may cause serious side effects including psychiatric (mental) symptoms and problems thinking (confusion, memory problems, speech difficulties). The doctor should be called immediately if, while taking PRIALT, you: are confused or disoriented, are less alert, see or hear things that are not real (hallucinations), have changes in mood or consciousness.

Your doctor may stop your treatment with PRIALT, give you other medicines, or require you to be hospitalized if you experience any of these symptoms.

You should not be given PRIALT if you:

  • are allergic to PRIALT or any of its ingredients
  • have a condition or are receiving a treatment that would cause an injection in your spinal fluid to be unsafe
  • have or had a mental illness called psychosis (a loss of contact with reality, usually including delusions (false beliefs about what is taking place or who one is) or hallucinations (seeing or hearing things that aren't real))

PRIALT may cause or worsen depression, which increases the risk of suicide. People 65 years of age and older have a higher risk for confusion with PRIALT. Taking certain other medicines along with PRIALT may raise the risk of having problems with thinking or alertness. Tell your doctor about all the medicines you are taking.

Meningitis (inflammation of the protective membranes covering the brain and spinal cord) or other infections can happen if the infusion device becomes contaminated. Tell your doctor right away if you have fever, headache, stiff neck, changes in mental status (feeling tired, confused, disoriented), nausea, vomiting, and/or seizures as these may be symptoms of developing meningitis.

PRIALT may cause unconsciousness or reduced mental alertness. Avoid activities where you need to be alert, awake, and have full control of your body (activities like operating machinery or driving a car) during treatment with PRIALT.

Tell the doctor if you experience new or worsening muscle pain, soreness, weakness or if your urine is dark in color as this could be a sign of rare but serious muscle side effects.

You should also tell the doctor if you are pregnant, plan to become pregnant or if you are breastfeeding.

The most common side effects of PRIALT include dizziness, nausea, confusion, and uncontrolled eye movements. These are not all the possible side effects of PRIALT. Talk to your doctor about any side effects you may be experiencing.

Indication

PRIALT is a prescription medicine used to treat severe chronic pain in adults who cannot take other treatments or when other treatments do not work, stop working, or cause bothersome side effects. PRIALT can only be delivered by or under the direction of a doctor who injects the medicine into your spinal fluid through a special device (a procedure called intrathecal infusion) and should only be used in patients who are appropriate for the procedure.

You are encouraged to report negative side effects of prescription drugs to the FDA. To report suspected adverse reactions, contact the FDA at 1‑800‑FDA‑1088 or www.FDA.gov/medwatch. You may also contact TerSera Therapeutics at 1‑844‑334‑4035 or medicalinformation@tersera.com.

Please see Full Prescribing Information, including Boxed Warning.

Important Safety Information and Indication

PRIALT may cause serious side effects including psychiatric (mental) symptoms and problems thinking (confusion, memory problems, speech difficulties). The doctor should be called immediately if, while taking PRIALT, you: are confused or disoriented, are less alert, see or hear things that are not real (hallucinations), have changes in mood or consciousness.

Your doctor may stop your treatment with PRIALT, give you other medicines, or require you to be hospitalized if you experience any of these symptoms.

You should not be given PRIALT if you:

  • are allergic to PRIALT or any of its ingredients
  • have a condition or are receiving a treatment that would cause an injection in your spinal fluid to be unsafe
  • have or had a mental illness called psychosis (a loss of contact with reality, usually including delusions (false beliefs about what is taking place or who one is) or hallucinations (seeing or hearing things that aren't real))

PRIALT may cause or worsen depression, which increases the risk of suicide. People 65 years of age and older have a higher risk for confusion with PRIALT. Taking certain other medicines along with PRIALT may raise the risk of having problems with thinking or alertness. Tell your doctor about all the medicines you are taking.

Meningitis (inflammation of the protective membranes covering the brain and spinal cord) or other infections can happen if the infusion device becomes contaminated. Tell your doctor right away if you have fever, headache, stiff neck, changes in mental status (feeling tired, confused, disoriented), nausea, vomiting, and/or seizures as these may be symptoms of developing meningitis.

PRIALT may cause unconsciousness or reduced mental alertness. Avoid activities where you need to be alert, awake, and have full control of your body (activities like operating machinery or driving a car) during treatment with PRIALT.

Tell the doctor if you experience new or worsening muscle pain, soreness, weakness or if your urine is dark in color as this could be a sign of rare but serious muscle side effects.

You should also tell the doctor if you are pregnant, plan to become pregnant or if you are breastfeeding.

The most common side effects of PRIALT include dizziness, nausea, confusion, and uncontrolled eye movements. These are not all the possible side effects of PRIALT. Talk to your doctor about any side effects you may be experiencing.

Indication

PRIALT is a prescription medicine used to treat severe chronic pain in adults who cannot take other treatments or when other treatments do not work, stop working, or cause bothersome side effects. PRIALT can only be delivered by or under the direction of a doctor who injects the medicine into your spinal fluid through a special device (a procedure called intrathecal infusion) and should only be used in patients who are appropriate for the procedure.

You are encouraged to report negative side effects of prescription drugs to the FDA. To report suspected adverse reactions, contact the FDA at 1‑800‑FDA‑1088 or www.FDA.gov/medwatch. You may also contact TerSera Therapeutics at 1‑844‑334‑4035 or medicalinformation@tersera.com.

Please see Full Prescribing Information, including Boxed Warning.

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