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What should I expect from treatment with PRIALT?

Many people get pain relief with PRIALT. Patients may respond differently to a drug, including whether or not they develop side effects. When side effects do develop, they may be easily managed, or may go away after a short time on their own.

Because no one can tell ahead of time which side effects a patient will experience, how serious they will be, or how long they will last, patients should tell their healthcare provider whenever any kind of side effects occur.

When should I contact my doctor?

Severe psychiatric symptoms and neurological impairment may occur during treatment with PRIALT.

Patients should contact their doctor or other healthcare provider immediately if they experience:

  • A change in mental state (feeling very sleepy, confused, disoriented, and not as alert)
  • A change in mood or perception (feeling increasingly depressed, defeated, angry, or short tempered) or experience hallucinations, or unusual tactile sensations
  • Thoughts of self-harm or committing suicide
  • Vomiting and feeling sick to the stomach; have seizures, a fever, a headache, and/or a stiff neck (symptoms of meningitis)
  • New or worsening muscle pain, soreness or weakness along with darkened urine
  • Insufficient pain relief
  • In ability to maintain a normal level of physical activity         


What else could I feel or report to my healthcare provider or caregiver?

Meningitis is a serious infection of the covering of the spinal cord and fluid. Meningitis can occur with intrathecal therapy if any portion of the pump system accidentally gets infected. 

Signs and symptoms include:

  • Fever
  • Headache
  • Stiff neck
  • Sudden fatigue, confusion or disorientation
  • Nausea or vomiting
  • Occasionally, seizures         

Meningitis rarely occurs with internal infusion pumps, but it can happen more often with external pump systems. When the pump is outside the body, the most common cause of meningitis is a disconnected catheter.