About Severe Chronic Pain

What is severe chronic pain?

Severe chronic pain can be the result of an underlying disease or medical condition, an injury, a medical treatment (such as surgery), or inflammation.



How does your body feel pain?

Pain signals travel from the site of injury through nerve channels in the spine to reach the brain.

In order for the signal to travel between the pain source and your brain, it passes through nerve channels with the help of chemicals that can cross the microscopic nerve pathways. These chemicals are released from channels including what is known as an “N-type calcium channel.” When N-type calcium channels are blocked, it prevents the pain signal from traveling between nerves.

Pain with a neuropathic component is associated with several conditions including, but not limited to:

  • Cancer
  • Complex regional pain syndrome
  • Diabetic neuropathy
  • Failed back surgery syndrome
  • HIV-related neuropathy
  • Lumbar radiculopathy
  • Multiple sclerosis
  • Phantom limb syndrome
  • Spinal cord injury
  • Tumor compression

Challenges in treating severe chronic pain

Over-the-counter medications, such as ibuprofen, and oral narcotics are two of the most common treatments for severe chronic pain. Over time, you may not receive enough pain relief at lower dosage levels, and you may become intolerant or have side effects associated with increased dosage.

If you have severe chronic pain and your pain treatment is not working, talk to your doctor about whether PRIALT may be able to help manage your pain.

Non narcotic pain medication

Results in animal studies show that PRIALT prevents pain signals from being transmitted.

PRIALT patient resources

Get the help and support you need to find an effective treatment for your severe chronic pain.