Patient Resources

Understand what to expect from chronic pain treatment with PRIALT

In your search for the pain therapy that works for you, many thoughts may run through your head, positive and negative. How you feel is important, and worth being heard. We’re here to help you better understand how PRIALT can help you manage your severe chronic pain.

How your chronic pain medication is delivered is important.

Pain signals travel from the site of injury through nerve channels in the spine to reach the brain. With PRIALT intrathecal therapy (IT), a pump is placed in the body with a line that delivers medication directly into the spinal fluid. The line can be placed close to where your specific injury or problem is located. IT therapy may help reduce the amount of oral medication you use to block pain because the medication enters the body right where pain signals travel.

Illustration of how chronic pain medication is delivered

Your chronic pain may be more than one type of pain.

Your chronic pain condition may be a result of more than one cause—damage to body tissues (nociceptive), damage to the nervous system (neuropathic), or a mix of the two. These causes of pain can be described as pain types.

Pain that is partly neuropathic can show up in many different conditions*:

  • Cancer-related pain
  • Complex regional pain syndrome
  • Diabetic neuropathy
  • Failed back surgery syndrome
  • HIV-related neuropathy
  • Lumbar radiculopathy
  • Multiple sclerosis
  • Phantom limb
  • Spinal cord injury
  • Tumor compression

*This list does not cover all of the pain conditions that have neuropathic pain.

Neuropathic pain may not respond to certain medications.

PRIALT, like opioids, has been studied in many types of severe chronic pain, but may not be appropriate for all patients.

PRIALT may be an option for your severe chronic pain.

PRIALT, a non-opioid, binds to N-type calcium channels in the spinal cord according to results from animal studies. This prevents pain signals from reaching the brain. The exact way PRIALT works in people with severe chronic pain is unknown. In clinical studies, PRIALT has been shown to help relieve different types of pain—nociceptive, neuropathic, and mixed.

In a 3-week clinical study, the number of people taking PRIALT who stopped because of side effects was similar to people taking placebo.

Percent of people ending therapy because of side effects

PRIALT = 5.4%
PLACEBO = 4.6%

The most common side effects of PRIALT include dizziness, nausea, confusion, and uncontrolled eye movements. However, this is not a complete list of risk information for PRIALT.

Talk about what you should expect before starting therapy with PRIALT.

If you and your doctor decide that PRIALT is an appropriate treatment for you, you can start the process. To have the intrathecal infusion, a specially designed pump is implanted inside your body by a doctor, or used externally. If you already have the right pump, your doctor can fill your pump with PRIALT as he or she sees fit.

Find the right dose

Your doctor will work with you to slowly increase your dose of PRIALT, to minimize possible side effects, until you reach a dose that may help get you closer to your pain relief goal.

Take your time

When starting PRIALT, you will need to visit your doctor often to find the dose that works for you. It is important to be patient; it may take time to find your dose.


Talk about your treatment

Stay in close contact with your doctor. When you partner with your doctor, you are able to watch for side effects, identify any issues quickly, and better manage the treatment altogether.