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What does PRIALT treat?

PRIALT is a prescription medicine used to treat severe chronic pain in adults who cannot take other treatments or when other treatments do not work, stop working, or cause bothersome side effects. PRIALT can only be delivered by or under the direction of a doctor who injects the medicine into your spinal fluid through a special device (a procedure called intrathecal infusion).

What to expect when starting PRIALT

What does PRIALT treat?

PRIALT is a prescription medicine used to treat severe chronic pain in adults who cannot take other treatments or when other treatments do not work, stop working, or cause bothersome side effects. PRIALT can only be delivered by or under the direction of a doctor who injects the medicine into your spinal fluid through a special device (a procedure called intrathecal infusion).

With the help of your doctor, you can move forward with confidence

If you and your doctor decide that PRIALT is an appropriate treatment for you, you can start the process. To have the intrathecal infusion, a specially designed pump is implanted inside your body by a doctor. If you already have the right pump, your doctor can fill your pump with PRIALT as he or she sees fit.

Icon of vial of PRIALT

Find the right dose

Your doctor will work with you to slowly increase your dose of PRIALT, to minimize possible side effects, until you reach a dose that may help get you closer to your pain relief goal.

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Take your time

When starting PRIALT, you will need to visit your doctor often to find the dose that works for you. It is important to be patient; it may take time to find your dose.
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Talk about your treatment

Stay in close contact with your doctor. When you partner with your doctor, you are able to watch for side effects, identify any issues quickly, and better manage the treatment altogether.

In clinical studies, PRIALT has been shown to help relieve different types of pain – nociceptive, neuropathic, and mixed*

Study results included:

  • Low risk of granuloma (blockages at the tip of the intrathecal line)
  • No reports of death from overdose

There were similar results between PRIALT vs placebo† in the number of patients who discontinued treatment due to side effects.

Image showing percent of people who didn't continue due to side effects. PRIALT = 5.4% (n=6/112) versus PLACEBO = 4.6% (n=5/108). Image showing percent of people who didn't continue due to side effects. PRIALT = 5.4% (n=6/112) versus PLACEBO = 4.6% (n=5/108).

The most common side effects (more than 25 out of 100 patients) of PRIALT include dizziness, nausea, confusion, and uncontrolled eye movements. These are not all the possible side effects of PRIALT. Talk to your doctor for more information and about any side effects you may be experiencing.

*Nociceptive pain occurs from tissues damaged by physical or chemical agents, such as trauma, surgery, or chemical burns. Neuropathic pain occurs from diseases or damage to sensory nerves, such as in diabetic neuropathy or shingles.

†Placebo = substance with no active ingredient.

What about insurance coverage?

Get help to understand your coverage and costs for PRIALT

Find a doctor

Locate a doctor who specializes in severe chronic pain

Starting on PRIALT?

Get one-on-one support to help you start, and stay, on treatment

Important Safety Information

What is the most important information I should know about PRIALT?

PRIALT may cause serious side effects including severe mental (psychiatric) problems and problems thinking.

Contact your healthcare provider immediately if you experience any of the following side effects while on PRIALT:

  • Confusion or feeling less alert
  • See or hear things that are not real (hallucinations)
  • Memory problems
  • Difficulty speaking
  • Changes in mood, new or worsening depression or suicidal thoughts
  • New muscle pain or muscle cramps

Who should NOT take PRIALT?

You should not take PRIALT if:

  • You have a mental health condition called psychosis, described as a loss of contact with reality, which may include delusions (believing things that are not actually true), or hallucinations (seeing or hearing things that are not real)
  • You are allergic to PRIALT or to any of its ingredients

What are the other possible serious side effects of PRIALT?

Mental (psychiatric) problems, difficulty thinking. PRIALT may cause psychiatric problems or make it difficult to think properly. People who are 65 years of age and older have a higher risk for confusion. PRIALT may cause or worsen depression, which increases the risk of suicide.

Reduced mental alertness. PRIALT can reduce your mental alertness or cause you to become unconscious. While taking PRIALT, avoid activities that require you to be alert and awake, and have full control of your body – examples of activities to avoid include operating machinery or driving a car.

Muscle problems. PRIALT can cause rare but serious muscle problems. Tell your doctor if you have any of the following:

  • New or worsening muscle pain, soreness, or weakness
  • Dark-colored urine

What should I tell my doctor before receiving treatment with PRIALT?

  • Before receiving PRIALT, tell your doctor about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Certain medicines can increase the risk of experiencing confusion and reduced mental alertness with PRIALT.
  • Tell your doctor about all of your medical conditions, including if you are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed.

What are the most common side effects of PRIALT?

  • Dizziness
  • Nausea
  • Confusion
  • Uncontrolled eye movements

These are not all the possible side effects of PRIALT. Your doctor may stop treatment if serious side effects happen. Be sure to contact your healthcare team right away if you have questions or are worried about any side effects.

What does PRIALT treat?

PRIALT is a prescription medicine used to treat severe chronic pain in adults who cannot take other treatments or when other treatments do not work, stop working, or cause bothersome side effects. PRIALT can only be delivered by or under the direction of a doctor who injects the medicine into your spinal fluid through a special device (a procedure called intrathecal infusion).

You are encouraged to report negative side effects of prescription drugs to the FDA at 1‑800‑FDA‑1088 or www.FDA.gov/medwatch. You may also contact ESTEVE Pharmaceuticals, S.A. at 1‑888‑306‑6259 or drugsafety.us@esteve.com.

Please see accompanying Full Prescribing Information, including BOXED WARNING.

Important Safety Information

What is the most important information I should know about PRIALT?

PRIALT may cause serious side effects including severe mental (psychiatric) problems and problems thinking.

Contact your healthcare provider immediately if you experience any of the following side effects while on PRIALT:

  • Confusion or feeling less alert
  • See or hear things that are not real (hallucinations)
  • Memory problems
  • Difficulty speaking
  • Changes in mood, new or worsening depression or suicidal thoughts
  • New muscle pain or muscle cramps

Who should NOT take PRIALT?

You should not take PRIALT if:

  • You have a mental health condition called psychosis, described as a loss of contact with reality, which may include delusions (believing things that are not actually true), or hallucinations (seeing or hearing things that are not real)
  • You are allergic to PRIALT or to any of its ingredients

What are the other possible serious side effects of PRIALT?

Mental (psychiatric) problems, difficulty thinking. PRIALT may cause psychiatric problems or make it difficult to think properly. People who are 65 years of age and older have a higher risk for confusion. PRIALT may cause or worsen depression, which increases the risk of suicide.

Reduced mental alertness. PRIALT can reduce your mental alertness or cause you to become unconscious. While taking PRIALT, avoid activities that require you to be alert and awake, and have full control of your body – examples of activities to avoid include operating machinery or driving a car.

Muscle problems. PRIALT can cause rare but serious muscle problems. Tell your doctor if you have any of the following:

  • New or worsening muscle pain, soreness, or weakness
  • Dark-colored urine

What should I tell my doctor before receiving treatment with PRIALT?

  • Before receiving PRIALT, tell your doctor about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Certain medicines can increase the risk of experiencing confusion and reduced mental alertness with PRIALT.
  • Tell your doctor about all of your medical conditions, including if you are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed.

What are the most common side effects of PRIALT?

  • Dizziness
  • Nausea
  • Confusion
  • Uncontrolled eye movements

These are not all the possible side effects of PRIALT. Your doctor may stop treatment if serious side effects happen. Be sure to contact your healthcare team right away if you have questions or are worried about any side effects.

What does PRIALT treat?

PRIALT is a prescription medicine used to treat severe chronic pain in adults who cannot take other treatments or when other treatments do not work, stop working, or cause bothersome side effects. PRIALT can only be delivered by or under the direction of a doctor who injects the medicine into your spinal fluid through a special device (a procedure called intrathecal infusion).

You are encouraged to report negative side effects of prescription drugs to the FDA at 1‑800‑FDA‑1088 or www.FDA.gov/medwatch. You may also contact ESTEVE Pharmaceuticals, S.A. at 1‑888‑306‑6259 or drugsafety.us@esteve.com.

Please see accompanying Full Prescribing Information, including BOXED WARNING.

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